Peptide Science chemists may be interested to read the article recently published by Aline Moulin, Jean Martinez and Jean-Alain Fehrentz:
Synthesis of peptide aldehydes
Journal of Peptide Science 2007, 13, 1 - 15
Aline Moulin, Jean Martinez and Jean-Alain Fehrentz
Abstract: The functionalization of peptides and proteins by aldehyde groups has become the subject of intensive research since the discovery of the inhibition properties of peptide aldehydes towards various enzymes. Furthermore, peptide aldehydes are of great interest for peptide backbone modification or ligation reactions. This review focuses upon their synthesis, which has been developed following two main strategies. The first strategy consists of prior synthesis of the peptide, followed by the introduction of the aldehyde function. The second possible strategy uses -amino aldehydes as starting materials. After protection of the aldehyde, peptide elongation occurs. At the end of the synthesis, the aldehyde function can be unmasked.
Biologists may be interested to read the review by Mariola Kuczer, Grzegorz Rosinski and Danuta Konopinska:
Insect gonadotropic peptide hormones: some recent developments
Journal of Peptide Science 2007, 13, 1 - 15
Mariola Kuczer, Grzegorz Rosinski and Danuta Konopinska
Abstract: Gonadotropic peptides are a new generation of peptide hormone regulators of insect reproduction. They have been isolated from ovaries, oviducts, or brains of insects. The subject of this paper is insect peptides that exert stimulatory or inhibitory effects on ovarian development and oocyte maturation. On the basis of the literature data and the results of our investigations, the structure and biological properties of different groups of peptides are presented.