Peptide Highlights

by EPS Pool of Writers

Epigallocatechin Gallate – Unravelling its Effect on Amyloid and Toxic Oligomers

Posted on Feb 10th, 2018

Many medical disorders are associated with amyloid formation, Alzheimer disease (AD) and Parkinson disease (PD) being perhaps the most well-known. All such diseases have in common the pathological aggregation of a normally soluble polypeptide chain into a series of oligomeric intermediates and…

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Figuring Out the Configuration

Posted on Jan 10th, 2018

Peptides can sometimes exhibit unusual stereochemistry.  Occasionally, for example, the usual l-amino acid building block might be substituted with its mirror-image counterpart. Such features can impact on function, but may be subtle enough to evade detection via routine methods. In this article,…

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Bioorthogonal labeling of peptides and proteins-two recent examples

Posted on Nov 6th, 2017

Site-specific introduction of distinct molecules into proteins and peptides is a challenging task. It becomes even more challenging if the labeling reaction has to be performed in living systems. How can we overcome undesired cross reactions with functional groups on proteins other than our target…

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Where is the field of α-helix mimetics going?

Posted on Oct 1st, 2017

Protein-protein interactions (PPI) are promiscuous in many biological pathways and their dysfunction is related to several pathologies. Therefore, PPI modulators are not only important probes to understand biological processes, but potential agents for pharmaceutical intervention. Taking into…

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Pre-clinical Study Confirms Potential of Peptide Hydrogels As Localised Drug Delivery Vehicles

Posted on Aug 31st, 2017

Hydrogel-forming peptides have the ability to self-assemble into nanofibres, which can further form 3D networks of entangled fibrous structures, essentially affording a scaffold-like architecture. Within minutes of adding these short peptides to water in appropriate proportions, a gel is formed,…

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Non-Canonical Building Blocks Extend the Peptide Alphabet

Posted on Jun 14th, 2017

The use of non-canonical amino-acid building blocks for peptide synthesis is a flexible way of introducing functionalities not normally found in biological systems. Two recent papers on this theme, both from Journal of Peptide Science, are discussed. In the first (Grob et al., 2017), methionine…

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Native Chemical Ligation and Beyond: Recent Developments in Chemical Protein Synthesis

Posted on Apr 27th, 2017

The total chemical synthesis of proteins has been one of the most challenging topics of organic chemistry in 20th century. The discovery of solid phase peptide synthesis (SPPS) in 1963 by R.B. Merrifield and the development of native chemical ligation (NCL) in 1994 by Kent and coworkers enabled the…

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Will the discovery of cross-α amyloid-like fibrils herald a new definition of amyloid?

Posted on Mar 27th, 2017

In microorganisms, functional amyloid is often involved in virulence mechanisms. Staphylococcus aureus secretes a 22-residue phenol-soluble modulin α3 (PSMα3) peptide, capable of forming elongated fibrils, with the appearance and staining properties typical of amyloid. Researchers working to…

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Antimicrobial Peptides: Alternatives To Combat Bacterial Infections

Posted on Mar 1st, 2017

Due to the increasingly growth of antibiotics resistance, antimicrobial peptides (AMPs) with multiple modes of action have been considered as the alternatives to combat pathogens. Here, we discussed two recent research publications about the development of AMPs. The first example published on J.…

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Cyclic Peptides in Biological/Medicinal Chemistry

Posted on Feb 1st, 2017

In biological and medicinal chemistry, cyclic peptides have advantages over linear analogues, because of their enhanced metabolic stability and a better definition of their conformational mobility. In recent years, there has been a considerable increase in the use of cyclic peptides as tools to…

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Cysteine: an Essential Inessential Amino Acid

Posted on Jan 1st, 2017

Cysteine is not, of course, one of the ten “essential” proteinogenic α-amino acids that mammals require in their diet. In many other respects, however, cysteine is just as important as any of the "essential" amino acids (or, for that matter, any of the other nine "inessential" ones). In fact,…

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Daptomycin – A New Twist To An Old Tale

Posted on Dec 2nd, 2016

Daptomycin is no newcomer to the stage of antibiotics, yet its mechanism of action has been a source of controversy since its discovery over 30 years ago. Exciting results of a collaborative study between scientists in The Netherlands, Germany and the UK reported recently in PNAS (24th October),…

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