A Report on the 25th Polish Peptide Symposium

CONFERENCE REPORT 25th Polish Peptide Symposium, Wojanów, Poland, 8-12 September 2019. The history of Polish Peptides Symposia begun in Gdańsk, where the first meeting has been organized by Prof. G. Kupryszewski in 1967. The second Symposium was also organized near Gdańsk by Prof. A. Chimiak. Since then, this conference has become an important, permanent point in the calendar of Polish scientists associated with peptides. Now, after 52 years since the first Symposium, we met for the 25th time Continue reading

A Report on the Peptide Chemistry Day Symposium

CONFERENCE REPORT Peptide Chemistry Day Symposium, Zagreb, Croatia, 19 September 2019. The Peptide Chemistry Day Symposium was held on September 19, 2019 at the University of Zagreb. Members of the organizing and scientific committee were: Dr. sc. Ruža Frkanec, University of Zagreb, president Dr. sc. Andreja Jakas, Ruđer Bošković Institute Dr. sc. Adela Štimac, University of Zagreb Prof. dr. sc. Leo Frkanec, Ruđer Bošković Institute Arijana Mihalić, University of Zagreb, Croatia. The aim of the Continue reading

The Other Sanger Sequencing

Inspired by a recent celebration of the work of Martin and Synge, this article examines the role of chromatography in efforts to elucidate the primary structures of proteins. It touches on, as I have referred to it, ‘the other Sanger sequencing’ – the method by which the first protein sequence was determined. It goes on to highlight some recent work on the application of a displacement method to the separation of peptides (Kwiatkowski et al., Continue reading

A Report on the 9th International Meeting on Antimicrobial Peptides

CONFERENCE REPORT 9th International Meeting on Antimicrobial Peptides, Utreht, The Nederlands, 28–30 August 2019. The 9th IMAP (International Meeting on Antimicrobial Peptides) was held at the University of Utrecht, The Netherlands, from the 28th to the 30th of August, 2019 http://peptideconferences.org/imap-2019. Since its birth in 2012 in Leipzig, this annual Meeting has significantly attracted a growing number of participants, especially among young scientists with a common interest in peptide science. This has fostered an intensive Continue reading

A Report on the 14th Chemistry & Biology of Peptides Meeting

CONFERENCE REPORT 14th Chemistry & Biology of Peptides Meeting: Hot Topics. Wolverhampton, UK, 25th July 2019. On 25th July and in the midst of the latest European heatwave, the University of Wolverhampton hosted the 14th Chemistry & Biology of Peptides Meeting. Undeterred by such climatic extremes, 120 delegates assembled into the historic Chancellors Hall, a laudable testament to their commitment to peptide science as soaring temperatures broke record levels for the UK in July. This Continue reading

A Report on the 21st GFPP Meeting

CONFERENCE REPORT 21st GFPP Meeting Amboise, France 12–16 May 2019   The 21st meeting of the French Peptides and Proteins Group (GFPP) was held in Amboise 500 years and a couple of days after the death of Leonardo Da Vinci, who spent his last years in the Chateau du Clos-Lucé, located a few kilometers away from conference center, in the beautiful and historic Loire valley area. This conference followed earlier meetings that have taken place Continue reading

Kálmán Medzihradszky (1928-2019), In Memoriam

Professor Kálmán Medzihradszky, member of the Hungarian Academy of Sciences, 92, of Budapest, Hungary our fellow chemist colleague and friend who made significant contributions to the fields of peptide science and bioorganic chemistry research, died 20 May, 2019. Kálmán is survived by his wife Hédi, his daughter Zsófia and his son Dénes, grandchildren and great-grandchildren. Memorial services were held on Thursday, June 20 and Friday, June 21, 2019 in Budapest. Dr. Kálmán Medzihradszky (Rákoscsaba, 20 Continue reading

Why protein chemist chose phosphorus for protein bioconjugation?

In the last two decades, phosphorus-mediated chemoselective ligation reactions acquired the “gold” status for in vivo labeling of biomolecules. However, some drawbacks of phosphines, such as directing non-canonical amino acids (e.g. azides) as their reaction partners limits the scope of these reactions. Thus, for chemical approaches, targeting canonical amino acids on proteins as targets for site-specific conjugation are of prime importance. Indeed, protein chemists developed several methods using canonical amino acids as selective conjugation sites. Continue reading

Conjugates of Vancomycin and Cell-penetrating Peptides – New Weapons in the Armoury against Drug Resistant Bacteria

Staying one step ahead in the arms race against antibiotic resistant pathogenic bacteria is an ongoing challenge to the ingenuity of medicinal chemists. Multidrug-resistance has become a menacing threat to the antibiotic armoury used by clinicians to treat nosocomial and community-acquired bacterial infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most notorious of such hospital-acquired pathogens. Until recently, the glycopeptide antibiotic vancomycin (Van) was available as a last resort, to effectively treat patients suffering Continue reading