A Report on the 21st GFPP Meeting

CONFERENCE REPORT 21st GFPP Meeting Amboise, France 12–16 May 2019   The 21st meeting of the French Peptides and Proteins Group (GFPP) was held in Amboise 500 years and a couple of days after the death of Leonardo Da Vinci, who spent his last years in the Chateau du Clos-Lucé, located a few kilometers away from conference center, in the beautiful and historic Loire valley area. This conference followed earlier meetings that have taken place Continue reading

Kálmán Medzihradszky (1928-2019), In Memoriam

Professor Kálmán Medzihradszky, member of the Hungarian Academy of Sciences, 92, of Budapest, Hungary our fellow chemist colleague and friend who made significant contributions to the fields of peptide science and bioorganic chemistry research, died 20 May, 2019. Kálmán is survived by his wife Hédi, his daughter Zsófia and his son Dénes, grandchildren and great-grandchildren. Memorial services were held on Thursday, June 20 and Friday, June 21, 2019 in Budapest. Dr. Kálmán Medzihradszky (Rákoscsaba, 20 Continue reading

Why protein chemist chose phosphorus for protein bioconjugation?

In the last two decades, phosphorus-mediated chemoselective ligation reactions acquired the “gold” status for in vivo labeling of biomolecules. However, some drawbacks of phosphines, such as directing non-canonical amino acids (e.g. azides) as their reaction partners limits the scope of these reactions. Thus, for chemical approaches, targeting canonical amino acids on proteins as targets for site-specific conjugation are of prime importance. Indeed, protein chemists developed several methods using canonical amino acids as selective conjugation sites. Continue reading

PhD in Organic / Peptide Chemistry within a Leading Science Foundation Ireland Pharmaceutical Research Centre

The Synthesis & Solid State Pharmaceutical Centre (SSPC) is seeking a PhD candidate in Organic/Peptide Chemistry. The SSPC aims to position Ireland as a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing. It is a hub of Irish research expertise, comprising 8 HEIs (Research Performing Organizations) and 24 industry partners. Activities span the entire pharmaceutical production chain between Active Pharmaceutical Ingredients manufacturing and drug product formulation. SSPC has grown in research capacity and currently Continue reading

Conjugates of Vancomycin and Cell-penetrating Peptides – New Weapons in the Armoury against Drug Resistant Bacteria

Staying one step ahead in the arms race against antibiotic resistant pathogenic bacteria is an ongoing challenge to the ingenuity of medicinal chemists. Multidrug-resistance has become a menacing threat to the antibiotic armoury used by clinicians to treat nosocomial and community-acquired bacterial infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most notorious of such hospital-acquired pathogens. Until recently, the glycopeptide antibiotic vancomycin (Van) was available as a last resort, to effectively treat patients suffering Continue reading

Professor Maurice Manning receives International Award

Dr. Maurice Manning, professor of Cancer Biology at The University of Toledo College of Medicine and Life Sciences, was the recent recipient of an award at the World Congress on Neurohypophysial Hormones in Ein Gedi, Israel, in “Recognition for His Lifelong Contributions to the Field of Neurohypophysial Hormones.” In his award address, entitled “Design and Synthesis of Receptor Selective Oxytocin and Vasopressin Agonists and Antagonists: An Odyssey of Chance Encounters and Surprising Discoveries,” he paid tribute to all the Continue reading

Robert C. Sheppard (1932‐2019), In Memoriam

Robert (Bob) Sheppard, former Head of the Sub‐Division of Peptide Chemistry at the MRC Laboratory of Molecular Biology, Cambridge, UK, passed away at his home on 15th January 2019, aged 87. His legacy to peptide science is a substantial body of work on the development of novel solid supports and orthogonal Fmoc/t‐butyl‐based chemistry that enable solid phase peptide synthesis to be carried out under mild conditions. These were also adapted to novel automated instruments designed Continue reading

Louis A. Carpino (1927‐2019), In Memoriam

Dr Louis A. Carpino (91) passed away at home in Amherst, MA on Friday, January 4, 2019. He was a Professor Emeritus of Organic Chemistry at the University of Massachusetts Amherst. Dr L.A. Carpino was a pioneer in the development of amino‐protecting groups and coupling reagents for use in the synthesis of biologically active materials such as pharmaceuticals, polynucleotides, PNAs, peptides, and small proteins. His first significant contribution was the development of the tert‐butyloxycarbonyl (Boc) Continue reading