Nature’s Shotgun Proteomics

The mammalian immune system, as part of its response to a viral infection, does something akin to a shotgun proteomics experiment. Viral proteins are digested, and the resulting peptides are presented—as a mixture—in a form that can be recognised by circulating T cells. In this article, I follow the ‘experiment’ through its various stages, and discover that it is possible for a real-life proteomics experiment to pick up from where the in vivo processes left Continue reading

Bogdan Przemysław Liberek (1926-2018), In Memoriam

With deep sorrow and sadness we inform you that after a long illness Bogdan Liberek, Professor Emeritus at Faculty of Chemistry, University of Gdańsk, Poland, passed away on December 22, 2018 at the age of 93. Bogdan Liberek had rooted from the lab of the pioneer of polish peptide chemistry, world renowned late (†1982) Dr. Emil Taschner. He got M.Sc. in 1950 and Ph.D. degrees in 1958 in Taschner’s lab at the Faculty of Chemistry, Continue reading

Job Offer – Peptide Chemist

“Caring for the world… one person at a time” inspires and unites the people of Johnson & Johnson. This culture of caring is the focus of our corporate philosophy, that are anchored in the internationally applicable Credo. Janssen in Schaffhausen belongs to the group of Johnson & Johnson pharmaceutical companies and manufactures and develops high quality pharmaceutical products, active pharmaceutical ingredients (APIs), and medical devices. Senior Scientist in Small Molecule API Process R&D Peptide Group Continue reading

EPS Mobility Fellowships

The European Peptide Society (EPS) invites applications from PhD students for EPS Mobility Fellowships   Mobility and interdisciplinarity nowadays are important assets in research careers. The European Peptide Society provides fellowships for PhD students who want to visit another laboratory in Europe to acquire new methodology or perform experiments that are not possible at the home institution. Eligibility At the time of the application the PhD student must be member of the European Peptide Society Continue reading

Postdoctoral researcher position

Postdoctoral researcher position @ Vrije Universiteit Brussel, Brussels, Belgium   Topic: Peptide Hydrogels. Hydrogels are part of the modern drug delivery platforms and tissue regeneration. One important route towards slow release drug delivery and ‘soft’ media for cell proliferation involves the encapsulation of therapeutics/cells into hydrogels. At ORGC, short hydrogel-forming α-peptides (containing unmodified natural amino acids) were developed. Currently, the study of their physicochemical (rheology, IR, CryoTEM) and pharmacological profiles (e.g. cytotoxicity, in vitro and Continue reading

Thanatin – an Insect-derived Antimicrobial Peptide Active against Pathogenic Gram-negative Bacteria

Swiss researchers have recently revealed the mechanism by which the insect-derived antimicrobial peptide thanatin targets the intermembrane protein complex required for lipopolysaccharide (LPS) transport in Escherichia coli. Employing a series of elegant techniques directed at increasing levels of magnification and ultimately, structural determination by NMR, these researchers show how thanatin interferes with assembly of the seven-member macromolecular protein complex which forms a molecular bridge supporting ATP-driven transport of LPS from the inner membrane to the Continue reading

Peptide vaccines: the future of immunotherapy?

It is widely accepted that vaccines are valuable preparations for prevention against life-threatening diseases such as polio, measles and smallpox and their utilization led to control and/or eradication of aforementioned infectious diseases. Common drawbacks in classical vaccine formulations led to the development of less allergenic and more specific peptide vaccines that usually consist of 20-30 amino acids and an external adjuvant to enhance immunogenicity of peptide epitopes, which are normally weak antigens and could therefore Continue reading