Funded Ph.D. position at the School of Biological Sciences, University of Auckland

We are seeking a well-qualified and highly motivated candidate for the position of a doctoral student to carry out a peptide-based drug-design project involving a multi-disciplinary approach. The project targets the interaction between endoplasmic reticulum (ER) chaperone ERp44 and the collagenous hormone adiponectin. Adiponectin, abundantly and exclusively secreted from adipocytes (fat cells), exerts a wide range of beneficial functions against obesity-associated pathologies and is a potent biotherapeutic. In the ER, ERp44 tightly regulates oligomerization of Continue reading

A Report on the 2nd Meeting of the Italian Peptide Society

The 2nd meeting of the Italian Peptide Society (ItPS) has been held at the Congress Center of the University of Naples ‘Federico II’ on June 5-6, 2018. The event, organized with the efforts of the members of the ItPS Scientific Committee has had an high attendance with the participation of more than 80 members of the recently born Italian Peptide Society and some invited guests from Italy and foreign countries. During the two days meeting Continue reading

Small Proteins, Big Data

The possibility that a subset of biological molecules has been overlooked, and is waiting to be discovered, is always intriguing. For small proteins (proteins of around 100 amino acid residues or fewer) there is evidence to suggest that this is indeed the case. In this article, I examine the defining characteristics of small proteins and survey the methods by which such proteins are analysed. The graphical abstract depicts NMR models of human sarcolipin (image of Continue reading

10th International Peptide Symposium and 55th Japanese Peptide Symposium

Dear European Peptide Society Members, As you may be aware, the 10th International Peptide Symposium (10th IPS), in conjunction with the 55th Japanese Peptide Symposium (55th JPS), will be held this coming December 3 to 7 in Kyoto, Japan. (https://www.aeplan.co.jp/10thips/) Scheduled talks include Plenary Lectures to be given by Professor Dale Boger (The Scripps Institute) and Professor William DeGrado (University of California, San Francisco), and presentations by invited speakers working on different fields in peptide Continue reading

Inhibition of Amyloidogenesis by Synthetic Enantiomeric Peptides

A synthetic peptide composed of alternating L- and D-amino acid residues has been recently shown to inhibit aggregation and reduce toxic effects in neuroblastoma cells, of the beta-amyloid peptide, Aβ, implicated in Alzheimer’s disease. In contrast, a “twin” peptide with the same sequence, but with all L-amino acid residues, had no inhibitory effect on amyloidogenesis or toxicity of Aβ. For more please download PDF file. Contributed by Susan J. Tzotzos Susan Tzotzos works for the Continue reading

New enzymatic approaches for the generation of peptide and protein conjugates

Enzymatic conjugation of peptides and their analogues to other peptides or proteins is considered to be an exciting field in protein chemistry. Besides Sortase A, Butelase and Transglutaminase, the field offers attractive possibilities with respect to its broad spectrum and simplicity. Nevertheless, certain issues such as the length of the peptide tag, sophisticated purification protocols to separate enzymes from the product and high amounts of enzymes used limit the scope of these approaches. In this Continue reading

Peptides as invaluable tools in the search for innovative analgesics

Pain is a quite frequent complaint after injuries and accompanying different pathologies, which remains poorly treated for a number of patients. Pain involves extremely complex/interrelated series of signaling and modulatory pathways of the nervous system. Within them, the contribution to pain sensation and transmission of different ion channels and regulatory proteins center the attention in recent years. Here, peptides are paying a key role in better understanding how the direct modulation of these channels or the Continue reading

Miklós Bodanszky Award 2018

The Miklos Bodanszky Award is presented every two years, during the European Peptide Symposium, in commemoration of Miklos Bodanszky’s contributions to peptide research, to a young scientist who has in the opinion of the General Assembly of the Society made the most outstanding contribution to peptide research in the period of maximum ten years after obtaining the PhD degree. The Award is presented during the EPS Symposium and is sponsored by BCN Peptides. The 2018 Continue reading

Leonidas Zervas Award 2018

The Leonidas Zervas Award is presented in commemoration of his outstanding contributions to peptide science. The award is given to the scientist who has made the most outstanding contributions to the chemistry, biochemistry and/or biology of peptides in the five years preceding the date of selection, and is sponsored by the donation of Dr. Rao Makineni. The 2018 awardee is Christian P. R. Hackenberger. Congratulations! Christian P. R. Hackenberger, born 1976 in Osnabrück, studied chemistry Continue reading