Conjugates of Vancomycin and Cell-penetrating Peptides – New Weapons in the Armoury against Drug Resistant Bacteria

Staying one step ahead in the arms race against antibiotic resistant pathogenic bacteria is an ongoing challenge to the ingenuity of medicinal chemists. Multidrug-resistance has become a menacing threat to the antibiotic armoury used by clinicians to treat nosocomial and community-acquired bacterial infections. Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most notorious of such hospital-acquired pathogens. Until recently, the glycopeptide antibiotic vancomycin (Van) was available as a last resort, to effectively treat patients suffering Continue reading

Professor Maurice Manning receives International Award

Dr. Maurice Manning, professor of Cancer Biology at The University of Toledo College of Medicine and Life Sciences, was the recent recipient of an award at the World Congress on Neurohypophysial Hormones in Ein Gedi, Israel, in “Recognition for His Lifelong Contributions to the Field of Neurohypophysial Hormones.” In his award address, entitled “Design and Synthesis of Receptor Selective Oxytocin and Vasopressin Agonists and Antagonists: An Odyssey of Chance Encounters and Surprising Discoveries,” he paid tribute to all the Continue reading

Robert C. Sheppard (1932‐2019), In Memoriam

Robert (Bob) Sheppard, former Head of the Sub‐Division of Peptide Chemistry at the MRC Laboratory of Molecular Biology, Cambridge, UK, passed away at his home on 15th January 2019, aged 87. His legacy to peptide science is a substantial body of work on the development of novel solid supports and orthogonal Fmoc/t‐butyl‐based chemistry that enable solid phase peptide synthesis to be carried out under mild conditions. These were also adapted to novel automated instruments designed Continue reading

Louis A. Carpino (1927‐2019), In Memoriam

Dr Louis A. Carpino (91) passed away at home in Amherst, MA on Friday, January 4, 2019. He was a Professor Emeritus of Organic Chemistry at the University of Massachusetts Amherst. Dr L.A. Carpino was a pioneer in the development of amino‐protecting groups and coupling reagents for use in the synthesis of biologically active materials such as pharmaceuticals, polynucleotides, PNAs, peptides, and small proteins. His first significant contribution was the development of the tert‐butyloxycarbonyl (Boc) Continue reading

Bioactive peptides from food protein degradation: Legume peptides

Animal and plant proteins, upon in vitro or in vivo digestion, have not only a nutritional role but are a rich source of bioactive peptides initially encrypted in the native protein sequences. The activities of these peptides range from antioxidant, antihypertensive or anti-obesity to antimicrobial or antitumoral. To illustrate the diversity of food-derived active peptides and their possible benefits for health, in this short report I have compiled a few recent examples of peptides isolated Continue reading

Postdoctoral research position on antimicrobial peptides at Uppsala University

This is a two year fixed salary position in peptide pharmacognosy. You will work in research focused on antimicrobial peptides of animal origin. The research involves discovery and characterization of antimicrobial peptides as well as studying their antibiotic and immunological properties. For more information please visit the Uppsala University job announcement page at https://www.uu.se/en/about-uu/join-us/details/?positionId=253487  (deadline 5th of April).

Nature’s Shotgun Proteomics

The mammalian immune system, as part of its response to a viral infection, does something akin to a shotgun proteomics experiment. Viral proteins are digested, and the resulting peptides are presented—as a mixture—in a form that can be recognised by circulating T cells. In this article, I follow the ‘experiment’ through its various stages, and discover that it is possible for a real-life proteomics experiment to pick up from where the in vivo processes left Continue reading

Bogdan Przemysław Liberek (1926-2018), In Memoriam

With deep sorrow and sadness we inform you that after a long illness Bogdan Liberek, Professor Emeritus at Faculty of Chemistry, University of Gdańsk, Poland, passed away on December 22, 2018 at the age of 93. Bogdan Liberek had rooted from the lab of the pioneer of polish peptide chemistry, world renowned late (†1982) Dr. Emil Taschner. He got M.Sc. in 1950 and Ph.D. degrees in 1958 in Taschner’s lab at the Faculty of Chemistry, Continue reading

Job Offer – Peptide Chemist

“Caring for the world… one person at a time” inspires and unites the people of Johnson & Johnson. This culture of caring is the focus of our corporate philosophy, that are anchored in the internationally applicable Credo. Janssen in Schaffhausen belongs to the group of Johnson & Johnson pharmaceutical companies and manufactures and develops high quality pharmaceutical products, active pharmaceutical ingredients (APIs), and medical devices. Senior Scientist in Small Molecule API Process R&D Peptide Group Continue reading