In late October 2013, a special meeting organized by two chemical committees of the Hungarian Academy of Sciences was held. The Hungarian Peptide Chemistry Committee (lead by Prof. Gábor Mező, Eötvös Loránd University) and the Hungarian Coordination Chemistry Committee (lead by Prof. Etelka Farkas, University of Debrecen) developed a joint, one-day mini-symposium to submit some research topics worked on the members of the committees .
The main goal of the meeting was to find some joint projects on which the researchers can work together in the future. There were close to 80 participants on the mini-symposium that was held at the Eötvös Loránd University in Budapest. Fifteen lectures were presented in three sections and three lead scientists (Prof. Ferenc Hudecz, the president of the European Peptide Society (EPS), Prof. Botond Penke the National representative of EPS and Prof. Imre Sóvágó, chair of international advisory committee of International Symposium on Applied Bioinorganic Chemistry series were asked to chair the sections.
In the first part, the speakers presented results and strategies of targeted tumour therapy including different peptides as targeting moieties as well as peptide-drug conjugates. Among the possible drug molecules metal complexes e.g. ferrocene derivatives were also mentioned. In addition, the application of peptide-chelator conjugates for complexing radio metal ions was demonstrated as an effective tumour labelling procedure for PET. The kinetic of the deamidation of labile NGR peptides as targeting moieties, and their rearrangement to isoDGR peptides were indicated by NMR studies. Further potential carriers like foldamers with sugar amino acid derivatives and semisynthetic lipoproteins with fluorescent cholesterol anchor were also presented.
In the second section the complexation properties of peptide ligands were summarized. The metal binding characteristics of hydroxamic acid containing peptides were also demonstrated. The structural studies of metal complexes with electron spin resonance spectroscopy and chiroptical methods were outlined. At the end of this part the representative of ABL&E-JASCO Hungary Kft. that sponsored the meeting introduced new CD instruments developed by the company.
In the final section an overview of the connection between metals, proteins and coordination chemistry was given followed by some special area of metal-protein interactions. Interesting lectures about the potential binding sites of ZnT3 zinc transporter protein, and regulation of artificial protein based metallonucleases could be listened by the audience. Finally some results in the area of the interaction of toxic metal ions with metal binding sites of metal-.dependent regulatory proteins and the influence of metal ions on β-amyloid aggregation were presented.
Contributed by Gábor Mező and Etelka Farkas