PhD in Organic / Peptide Chemistry within a Leading Science Foundation Ireland Pharmaceutical Research Centre

The Synthesis & Solid State Pharmaceutical Centre (SSPC) is seeking a PhD candidate in Organic/Peptide Chemistry. The SSPC aims to position Ireland as a Global Hub of Pharmaceutical Process Innovation and Advanced Manufacturing. It is a hub of Irish research expertise, comprising 8 HEIs (Research Performing Organizations) and 24 industry partners. Activities span the entire pharmaceutical production chain between Active Pharmaceutical Ingredients manufacturing and drug product formulation. SSPC has grown in research capacity and currently has >130 active researchers.

Location: Department of Chemistry, Royal College of Surgeons in Ireland (RCSI)
https://www.rcsi.com/dublin/research-and-innovation/research/research-themes/chemistry-and-pharmaceutical-sciences

Project background and description: Peptides are one of the fastest growing classes of new drugs. Their therapeutic potential is exploited in multiple therapeutic areas, including metabolic diseases, endocrinology, oncology, gastroenterology, cardiovascular, neurology, anti-infective, but can be limited by shortcomings associated with their method of production and their bio-stability. This PhD project aims to develop new solutions for the efficient and sustainable production of synthetic peptides, as well as for the generation of metabolically stable analogues. They include the combination of continuous flow, solid phase and green chemistries, as well as a novel proprietary peptidomimetic technology, respectively. These approaches will be applied to the synthesis of peptides, their analogues and peptide-drug conjugates.

Qualification: the candidate should have a master or engineer degree (or equivalent) in the field of organic/synthetic or medicinal/pharmaceutical chemistry. Experience in peptide synthesis would be an advantage.

Application procedure: please send a cover letter and a CV including names and contact details of two referees to Prof. Marc Devocelle (mdevocelle@rcsi.ie). Further details can be obtained by email to Marc Devocelle.

Closing date: applications must be received by the 31st of August 2019.
Start date: 01st of October 2019, or earlier if possible.

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