Due to the increasingly growth of antibiotics resistance, antimicrobial peptides (AMPs) with multiple modes of action have been considered as the alternatives to combat pathogens. Here, we discussed two recent research publications about the development of AMPs. The first example published on J. Pept. Sci. demonstrated the N-terminal modification with lipid acid significantly improved the cationic AMPs’ antibacterial and antifungal activities with secondary structure changes. The other research article combined in silico computational screening tool and experimental activity test for AMPs optimisation. Both the chemical modification and in silico optimisation would assist the potent antimicrobial agents development.
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Contributed by Wenyi Li
Wenyi Li received his undergraduate in 2009 and Master of Science in 2012 at Lanzhou University, China. After then, he moved to Australia to pursue his doctoral degree and finished at September 2016 in University of Melbourne under the supervision of Prof John D. Wade and Prof Frances Separovic. During his PhD, he mainly worked on the peptide chemistry and physical chemistry to develop the cationic antimicrobial peptides and investigate their mechanism. Since October 2016, he joined the research group of Prof Christian Hackenberger in FMP-Berlin, Germany, as a postdoc to develop new methods for the semi-synthesis of the Alzheimer’s disease related tau protein, and further study physiological behaviour of tau protein in vitro.