• Peptide Highlights

    Small peptide and amino acid derivatives in the search for SARS-CoV2 main protease inhibitors

    December 21, 2020

    In times of COVID-19 pandemic, science is advancing very fast, faster than ever. The first vaccines and various diagnosis probes are already in the market. There is an approved drug, remdesivir, and...
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  • Peptide Highlights

    Peptide Therapeutics for COVID-19

    September 18, 2020

    As the world struggles to cope with the current COVID-19 pandemic, in this edition of “Peptide Highlights” we present a survey of peptide drugs which are being investigated as potential therapies...
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  • Peptide Highlights

    Imine-derived macrocyclic peptides

    July 19, 2020

    In recent years, macrocyclic peptides are attracting a growing attention of pharmaceutical/biotech companies and academic groups. Their intermediate size, in-between small-molecule drugs and...
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  • Peptide Highlights

    Life imitates cookery: lysinoalanine crosslinks in peptides and proteins

    June 5, 2020

    The lysinoalanine crosslink – a type of protein post-translational modification – was initially discovered in vitro and later found to occur in cooked and processed food. Curiously, the same kind...
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  • Peptide Highlights

    The hitchhiker´s guide to chemoselectivity in chemical protein synthesis

    March 10, 2020

    Posttranslational modifications (PTMs) allow proteins to perform a variety of physiological functions. Thus, it is of prime importance to elucidate their role on proteins in physiological and/or...
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  • Peptide Highlights

    Peptide Drugs of the Decade

    December 30, 2019

    The approaching end of another decade prompted this short review of peptide drugs that successfully reached the European market from 2010 to the present. The article also gives a comparison of...
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  • Peptide Highlights

    “Sweet” Peptides

    November 25, 2019

    Naturally occurring glycopeptides (GPs, peptide + sugar) and glycoproteins are crucial players in many biological processes. N- and O-glycosylation is in fact one of the most important...
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  • Peptide Highlights

    The Other Sanger Sequencing

    September 27, 2019

    Inspired by a recent celebration of the work of Martin and Synge, this article examines the role of chromatography in efforts to elucidate the primary structures of proteins. It touches on, as I have...
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  • Peptide Highlights

    Why protein chemist chose phosphorus for protein bioconjugation?

    July 10, 2019

    In the last two decades, phosphorus-mediated chemoselective ligation reactions acquired the “gold” status for in vivo labeling of biomolecules. However, some drawbacks of phosphines, such as...
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  • Peptide Highlights

    Conjugates of Vancomycin and Cell-penetrating Peptides – New Weapons in the Armoury against Drug Resistant Bacteria

    June 9, 2019

    Staying one step ahead in the arms race against antibiotic resistant pathogenic bacteria is an ongoing challenge to the ingenuity of medicinal chemists. Multidrug-resistance has become a menacing...
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