Figuring Out the Configuration

George PrestonPeptides can sometimes exhibit unusual stereochemistry.  Occasionally, for example, the usual l-amino acid building block might be substituted with its mirror-image counterpart. Such features can impact on function, but may be subtle enough to evade detection via routine methods. In this article, I highlight some innovative mass-spectrometry-based approaches to the characterisation of peptides with exotic stereochemical features.

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Contributed by George Preston

George is a Research Associate at King’s College London. In his research, he is interested in using peptides to understand more about protein covalent modifications, and he currently works on the “EXPOsOMICS” project (

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