Journal of Peptide Science: two outstanding reviews, giving an insight into new opportunities for peptide science

Journal of Peptide Science  just published two outstanding reviews, giving an insight into new opportunities for peptide science.

Both reviews are based on the Josef Rudinger Award Lecture (Stephen Kent) and the Zervas Award Lecture (Helma Wennemers), both given at the 31st European Peptide Symposium 2010 in Copenhagen, Denmark.

a. Stephen Kent and co-workers give a summary of new synthetic approaches enabling the preparation of new proteins and peptides.

Through the looking glass – a new world of proteins enabled by chemical synthesis
Stephen Kent, Youhei Sohma, Suhuai Liu, Duhee Bang, Brad Pentelute and Kalyaneswar Mandal (pages 428–436)

Article first published online: 4 JUN 2012 | DOI: 10.1002/psc.2421

Total synthesis of proteins by modern chemical ligation methods has enabled the routine use of mirror-image protein molecules in structural biology as well as the synthesis of crystalline protein molecules with full enzymatic activity. A practical total chemical synthesis of insulin has been achieved via a key ester-linked protein molecule of novel topology. Racemic protein crystallography has enabled the determination of X-ray structures of recalcitrant protein molecules.


b. Helma Wennemers shows how peptides can be used as catalysts for the synthesis on nano particles.

Peptides as asymmetric catalysts and templates for the controlled formation of Ag nanoparticles
Helma Wennemers (pages 437–441)



Article first published online: 31 MAY 2012 | DOI: 10.1002/psc.2422

Research in the Wennemers group focuses on the development of small molecules for functions that are fulfilled in nature by large macromolecules. The Zervas Award presentation focused on the use of tripeptides of the type H-Pro-Pro-Xaa as asymmetric catalysts and short peptides as templates for the controlled formation of silver nanoparticles.

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