The possibility that a subset of biological molecules has been overlooked, and is waiting to be discovered, is always intriguing. For small proteins (proteins of around 100 amino acid residues or fewer) there is evidence to suggest that this is indeed the case. In this article, I examine the defining characteristics of small proteins and survey the methods by which such proteins are analysed. The graphical abstract depicts NMR models of human sarcolipin (image of Protein Data Bank entry 1JDM created with NGL Viewer and embellished in Inkscape; see PDF for full citations).
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Contributed by George Preston
George is a Research Associate at King’s College London.