Thiol additive-free native chemical ligation

Photo Wenyi LiNative chemical ligation (NCL) commonly facilitates a peptide thioester with an N-terminal β-thiol peptide to form a native amide bond. Though many peptide thioester preparation strategies have been developed, it generally requires a large excess of exogenous thiol additives. Here I will discuss two recent reports focusing on thiol additive-free mediated NCL.

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Contributed by Wenyi Li

Wenyi Li received his doctoral degree by September 2016 in University of Melbourne under the supervision of Prof John D Wade and Prof Frances Separovic. During his PhD, he mainly worked on the peptide chemistry and physical chemistry to develop the cationic antimicrobial peptides and investigate their mechanism. His doctoral thesis has been awarded the Graham Johnston Best Thesis Award from Royal Australian Chemical Institute, Division of Medicinal Chemistry/Chemical Biology. Since October 2016, he joined the research group of Prof Christian Hackenberger in Leibniz-Forschungsinstitut for Molekulare Pharmakologie (FMP)-Berlin, Germany, as a postdoctoral fellow. Currently, he is supported as Leibniz-DAAD postdoctoral research fellow (2017-2018) in the same research group to develop new methods for the semi-synthesis of the Alzheimer’s disease-related tau protein, and further study physiological behaviour of tau protein in vitro.

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