• Peptide Highlights

    Epigallocatechin Gallate – Unravelling its Effect on Amyloid and Toxic Oligomers

    February 10, 2018

    Many medical disorders are associated with amyloid formation, Alzheimer disease (AD) and Parkinson disease (PD) being perhaps the most well-known. All such diseases have in common the pathological...
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  • Peptide Highlights

    Figuring Out the Configuration

    January 10, 2018

    Peptides can sometimes exhibit unusual stereochemistry.  Occasionally, for example, the usual l-amino acid building block might be substituted with its mirror-image counterpart. Such features can...
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  • Peptide Highlights

    Bioorthogonal labeling of peptides and proteins-two recent examples

    November 6, 2017

    Site-specific introduction of distinct molecules into proteins and peptides is a challenging task. It becomes even more challenging if the labeling reaction has to be performed in living systems. How...
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  • Peptide Highlights

    Where is the field of α-helix mimetics going?

    October 1, 2017

    Protein-protein interactions (PPI) are promiscuous in many biological pathways and their dysfunction is related to several pathologies. Therefore, PPI modulators are not only important probes to...
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  • Peptide Highlights

    Pre-clinical Study Confirms Potential of Peptide Hydrogels As Localised Drug Delivery Vehicles

    August 31, 2017

    Hydrogel-forming peptides have the ability to self-assemble into nanofibres, which can further form 3D networks of entangled fibrous structures, essentially affording a scaffold-like architecture....
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  • Peptide Highlights

    Non-Canonical Building Blocks Extend the Peptide Alphabet

    June 14, 2017

    The use of non-canonical amino-acid building blocks for peptide synthesis is a flexible way of introducing functionalities not normally found in biological systems. Two recent papers on this theme,...
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  • Peptide Highlights

    Native Chemical Ligation and Beyond: Recent Developments in Chemical Protein Synthesis

    April 27, 2017

    The total chemical synthesis of proteins has been one of the most challenging topics of organic chemistry in 20th century. The discovery of solid phase peptide synthesis (SPPS) in 1963 by R.B....
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  • Peptide Highlights

    Will the discovery of cross-α amyloid-like fibrils herald a new definition of amyloid?

    March 27, 2017

    In microorganisms, functional amyloid is often involved in virulence mechanisms. Staphylococcus aureus secretes a 22-residue phenol-soluble modulin α3 (PSMα3) peptide, capable of forming elongated...
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  • Peptide Highlights

    Antimicrobial Peptides: Alternatives To Combat Bacterial Infections

    March 1, 2017

    Due to the increasingly growth of antibiotics resistance, antimicrobial peptides (AMPs) with multiple modes of action have been considered as the alternatives to combat pathogens. Here, we discussed...
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  • Peptide Highlights

    Cyclic Peptides in Biological/Medicinal Chemistry

    February 1, 2017

    In biological and medicinal chemistry, cyclic peptides have advantages over linear analogues, because of their enhanced metabolic stability and a better definition of their conformational mobility....
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