• Peptide Highlights

    Bioactive peptides from food protein degradation: Legume peptides

    April 4, 2019

    Animal and plant proteins, upon in vitro or in vivo digestion, have not only a nutritional role but are a rich source of bioactive peptides initially encrypted in the native protein sequences. The...
    Read More

  • Peptide Highlights

    Nature’s Shotgun Proteomics

    February 26, 2019

    The mammalian immune system, as part of its response to a viral infection, does something akin to a shotgun proteomics experiment. Viral proteins are digested, and the resulting peptides are...
    Read More

  • Peptide Highlights

    Thanatin – an Insect-derived Antimicrobial Peptide Active against Pathogenic Gram-negative Bacteria

    January 3, 2019

    Swiss researchers have recently revealed the mechanism by which the insect-derived antimicrobial peptide thanatin targets the intermembrane protein complex required for lipopolysaccharide (LPS)...
    Read More

  • Peptide Highlights

    Peptide vaccines: the future of immunotherapy?

    December 8, 2018

    It is widely accepted that vaccines are valuable preparations for prevention against life-threatening diseases such as polio, measles and smallpox and their utilization led to control and/or...
    Read More

  • Peptide Highlights

    Targeted protein degradation as a new paradigm in drug discovery. Is there a role for peptides?

    October 24, 2018

    Despite the large number of new, therapeutically relevant proteins discovered in recent years, classical drug discovery strategies have not been particularly successful in finding suitable...
    Read More

  • Peptide Highlights

    Small Proteins, Big Data

    September 5, 2018

    The possibility that a subset of biological molecules has been overlooked, and is waiting to be discovered, is always intriguing. For small proteins (proteins of around 100 amino acid residues or...
    Read More

  • Peptide Highlights

    Inhibition of Amyloidogenesis by Synthetic Enantiomeric Peptides

    August 4, 2018

    A synthetic peptide composed of alternating L- and D-amino acid residues has been recently shown to inhibit aggregation and reduce toxic effects in neuroblastoma cells, of the beta-amyloid peptide,...
    Read More

  • Peptide Highlights

    New enzymatic approaches for the generation of peptide and protein conjugates

    June 6, 2018

    Enzymatic conjugation of peptides and their analogues to other peptides or proteins is considered to be an exciting field in protein chemistry. Besides Sortase A, Butelase and Transglutaminase, the...
    Read More

  • Peptide Highlights

    Peptides as invaluable tools in the search for innovative analgesics

    May 9, 2018

    Pain is a quite frequent complaint after injuries and accompanying different pathologies, which remains poorly treated for a number of patients. Pain involves extremely complex/interrelated series...
    Read More

  • Peptide Highlights

    Thiol additive-free native chemical ligation

    March 13, 2018

    Native chemical ligation (NCL) commonly facilitates a peptide thioester with an N-terminal β-thiol peptide to form a native amide bond. Though many peptide thioester preparation strategies have been...
    Read More